Optimizing the State Identities in Markov Models of Macroscopic Ion Channel Activity

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...

Applying hidden Markov models to the analysis of single ion channel activity.

Hidden Markov models have recently been used to model single ion channel currents as recorded with the patch clamp technique from cell membranes. The estimation of hidden Markov models parameters using the forward-backward and Baum-Welch algorithms can be performed at signal to noise ratios that are too low for conventional single channel kinetic analysis; however, the application of these algo...

Identification of hidden Markov models for ion channel currents. II. State-dependent excess noise

Hidden Markov modeling (HMM) techniques have been applied in the past few years to characterize single ion channel current events at low signal-to-noise ratios (SNR’s). In this paper, an adaptation of the forward-backward procedure and Baum–Welch algorithm is presented to model ion channel kinetics under conditions of correlated and state-dependent excess noise like that observed in patch-clamp...

Bayesian restoration of ion channel records using hidden Markov models.

Hidden Markov models have been used to restore recorded signals of single ion channels buried in background noise. Parameter estimation and signal restoration are usually carried out through likelihood maximization by using variants of the Baum-Welch forward-backward procedures. This paper presents an alternative approach for dealing with this inferential task. The inferences are made by using ...

Ion channel activity drives ion channel expression.